(Source: c0ldweather)

djprincessk:

stop-hammerkind:

srsfunny:

Glass Blower: Sculpting A Horse From Molten Glass

WHAT

#this bitch just said let there be horse and there was

djprincessk:

stop-hammerkind:

srsfunny:

Glass Blower: Sculpting A Horse From Molten Glass

WHAT

#this bitch just said let there be horse and there was

sashwrin:

Aperture science information posters

(Source: wintersoldeirs)

siggybaker:

mfw

(Source: riversclara)

youngmonsters:

The most spot on cosplay of Tom baker as the Doctor ever!!! 

youngmonsters:

The most spot on cosplay of Tom baker as the Doctor ever!!! 

queen-overlord:

bananaschnapple:

goldenboydean:

alice-isnt-mad-we-are:

nivalvixen:

exhumana:

ADOPTED BLACK

image

MIDDLE-AGED WOLF!

the vampire memoires

Agents of hydra.

Orange Is So Last Season

cleowho:

"…the crickety cricket stuff.."

Time Crash - 17th Nov, 2007

cleanfurry:

http://www.furaffinity.net/user/danji-isthmus/
visitheworld:

Nan Lian Garden on Diamond Hill / Hong Kong (by Michael MH).

visitheworld:

Nan Lian Garden on Diamond Hill / Hong Kong (by ).

fullofcomics:

Hal & Carol

Parallax: Emerald Night #1

visitheworld:

The old town centre of Aalborg / Denmark (by Finn Lyngesen).

visitheworld:

The old town centre of Aalborg / Denmark (by ).

thranduils-queen:

tacobell-canon:

Ladypug.

what
amuletbrothers:

mytra-fallen-angel:

bubbly-fallen-angel:

bltsl4:


your ship

THAT COMMENT MADE THIS ANALOGY SUDDENLY EVEN MORE ACCURATE IN AN AWFUL WAY


Supernatural STILL hasn’t appeared on this post with an accurate gif?

Because it hurts to much

no, it’s 

amuletbrothers:

mytra-fallen-angel:

bubbly-fallen-angel:

bltsl4:


image

your ship

THAT COMMENT MADE THIS ANALOGY SUDDENLY EVEN MORE ACCURATE IN AN AWFUL WAY

Supernatural STILL hasn’t appeared on this post with an accurate gif?

Because it hurts to much

no, it’s 

(Source: cybii-chan)

currentsinbiology:

Epigenetic tie to neuropsychiatric disorders found
Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain’s prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.



This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.
The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.
K Brami-Cherrier, A Anzalone, M Ramos, I Forne, F Macciardi, A Imhof, E Borrelli. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Molecular Psychiatry, 2014; DOI: 10.1038/mp.2014.67
Image via Resverlogix

currentsinbiology:

Epigenetic tie to neuropsychiatric disorders found

Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain’s prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.

K Brami-Cherrier, A Anzalone, M Ramos, I Forne, F Macciardi, A Imhof, E Borrelli. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Molecular Psychiatry, 2014; DOI: 10.1038/mp.2014.67

Image via Resverlogix